High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFκB family, ATF-2 and c-Jun to activate transcription.

稀释比 WB: 1/500-1/1000; IHC: 1/50-1/100

Western blot detection of HMGB1 in K562，Rat Brain，C6， 3T3，Hela cell lysates using HMGB1 Rabbit pAb (1:1000 diluted). Predicted band size:25kDa.Observed band size:25kDa.

Immunohistochemistry of HMGB1 in paraffin embedded Human tonsil using HMGB1 Rabbit pAb at dilution 1/100

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