产品信息

产品名称	产品编号	规格
Anti-Mouse PD-1(CD279) mAb	31550ES60	100 μg
	31550ES80	1 mg

 

产品简介

Programmed Death-1 (PD-1) is type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses). Two B7 family proteins, PD-L1 (also called B7-H1) and PD-L2, have been identified as PD-1 ligands. PD-1 is expressed on activated T cells, B cells, myeloid cells, and on a subset of thymocytes. PD-1 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. Binding of PD-1 to PD-L1 or PD-L2 results in the inhibition of TCR-mediated proliferation and cytokine production as well as BCR-mediated signaling. PD-1 likely has an inhibitory role in regulating immune responses.

 

产品性质

同种型	Human IgG4
缓冲液	1x PBS pH 7.4
克隆类型	Monoclonal Antibody
表达系统	Eukaryotic 293F
分子量	145 kDa
物种反应	Mouse
消光系数	1.42
纯度	＞97% as determined by SDS-PAGE；＞93% as determined by SEC-HPLC
活性	EC50=2.9 ng/mL

 

储存条件

-25~-15℃保存

 

注意事项

1. 避免反复冻融。

2. 本产品仅作科研用途。

3. 为了您的安全和健康，请穿实验服并佩戴一次性手套操作。

 

产品数据  

SDS-PAGE

SEC-HPLC

 

ELISA Data

 

Ver.CN20240508