The family of Trk receptor tyrosine kinases consists of TrkA, TrkB and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA.

推荐稀释比 WB:1/500-1/1000

Western blot analysis of Phospho-TrkA (tyr490)/TrkB (Tyr516) in K562, C6, 3T3 lysates using Phospho-TrkA/B (Tyr490/Tyr516) antibody.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.