Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.

推荐稀释比 IHC:1/50-1/100

Immunohistochemistry analysis of paraffin-embedded human colon cancer using LGR5 antibbody. High-pressure and temperature was used for antigen retrieval.

Immunohistochemistry analysis of paraffin-embedded Human colon Adenocarcinoma using LGR5 antibbody. High-pressure and temperature Tris-EDTA pH 8.5 was used for antigen retrieval.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.