The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

推荐稀释比 WB:1/500-1/1000;IF:1:50/1:200

Western blot analysis of Proteasome subunit alpha type 6 in K562, C6, 3T3, Hela lysates using Proteasome alpha 6 antibody.

Immunocytochemistry analysis of Proteasome subunit alpha type 6 (green) in Hela using Proteasome subunit alpha type 6 antibody,and DAPI(blue)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.