Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IF:1/50-1/200;ELISA:1/10000

Western blot analysis of CMKLR1 in various lysates using CMKLR1 antibody.

Western blot analysis of CMKLR1 in COLO205 lysates using ChemR23 antibody.

Western blot analysis of CMKLR1 in 293T lysates using ChemR23 antibody.

Western blot analysis of CMKLR1 in 293T lysates using CMKLR1 antibody.

Western blot analysis of CMKLR1 in HeLa and HUVEC lytsates using CMKLR1 antibody. The lane on the right is blocked with the synthesized peptide.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。