This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy. [provided by RefSeq, Jul 2008]

Immunocytochemistry

Immunocytochemistry analysis of Niemann Pick C2 (green) in U87-MG using Niemann Pick C2 antibody,and DAPI(blue).

Western

Western blot analysis of Niemann Pick C2 in Raw264.7, PC-12, C6 lysates using Niemann Pick C2 antibody.

Western

Western blot analysis of Niemann Pick C2 in Hela, A549, HL-60 lysates using Niemann Pick C2 antibody

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using Niemann Pick C2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.