This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunocytochemistry

Immunocytochemistry analysis of ACADM (green) in 293T using ACADM antibody,and DAPI(blue).

Western

Western blot analysis of ACADM/MCAD in rat muscle lysates using ACADM/MCAD antibody.

Western

Western blot analysis of ACADM/MCAD in Hela, A549, MCF-7, U251, C2C12 lysates using ACADM/MCAD antibody

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human tonsil using ACADM/MCAD antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.