[ 1 ]DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage

[ 2 ]Targeted Computed Tomography Visualization and Healing of Inflammatory Bowel Disease by Orally Delivered Bacterial-Flagella-Inspired Polydiiododiacetylene Nanofibers

[ 3 ]Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy

[ 4 ]SMAD4 Palmitoylation Drives a Metabolic-Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

[ 5 ]HLA-DR+ Schwann Cells Generate the Protumor Cancer-Neuron-Immune Niche in Head and Neck Squamous Cell Carcinoma

[ 6 ]TSPYL5 Promotes Triple-Negative Breast Cancer Metastasis by Antagonizing USP10-Mediated PTEN Stabilization to Unleash a ZEB1-Dependent EMT Program

[ 7 ]Niclosamide-loaded nanoparticles (Ncl-NPs) reverse pulmonary fibrosis in vivo and in vitro

[ 8 ]Chronic dental lighting disrupts blood-retinal barrier homeostasis via vascular and inflammatory pathways

[ 9 ]CRYL1 inhibits tumorigenesis and metastasis in clear cell renal cell carcinoma through upregulation of CASR

[ 10 ]The AGPS regulatory variant rs113671272 confers esophageal squamous cell carcinoma susceptibility through allele-specific MEIS3 binding and NF-κB activation in Chinese populations

[ 11 ]Biocompatible scaffolds constructed by chondroitin sulfate microspheres conjugated 3D-printed frameworks for bone repair

[ 12 ]Lipid-Based Nanocarriers Enabled Oral Delivery of Oleanolic Acid Derivative DKS26 for Diabetes Management

[ 13 ]Talin1 loss activates DRG neurons to accelerate bone remodeling and fracture healing in mice

[ 14 ]Eubacterium rectale Mitigates Inflammatory Bowel Disease via Modulation of Glutamine Metabolism Through the GLS2 and NF-κB Pathway

[ 15 ]ISGylation prevents autophagic degradation of STING and promotes antitumor immunity in lung cancer

[ 16 ]Efficient gene editing through an intronic selection marker in cells

[ 17 ]An oral phenylacrylic acid derivative suppressed hepatic stellate cell activation and ameliorated liver fibrosis by blocking TGF-β1 signalling

[ 18 ]Overcoming the cytoplasmic retention of GDOWN1 modulates global transcription and facilitates stress adaptation

[ 19 ]PDIA6 as a novel pharmacological target for metabolic dysfunction-associated steatohepatitis via alleviating endoplasmic reticulum stress

[ 20 ]Silica nanocarrier-mediated intracellular delivery of rapamycin promotes autophagy-mediated M2 macrophage polarization to regulate bone regeneration

[ 21 ]Immunoregulatory Bioinspired Hydrogel from Decellularized Amnion for Infected Wound Healing

[ 22 ]The Assessment of Dietary Organic Zinc on Zinc Homeostasis, Antioxidant Capacity, Immune Response, Glycolysis and Intestinal Microbiota in White Shrimp (Litopenaeus vannamei Boone, 1931)

[ 23 ]CAR-T-Cell Therapy for Solid Tumors Positive for Fibronectin Extra Domain B

[ 24 ]Effects of Dietary Mannan Oligosaccharides on Non-Specific Immunity, Intestinal Health, and Antibiotic Resistance Genes in Pacific White Shrimp Litopenaeus vannamei

[ 25 ]Isosteviol Sodium Ameliorates Dextran Sodium Sulfate-Induced Chronic Colitis through the Regulation of Metabolic Profiling, Macrophage Polarization, and NF-κB Pathway

[ 26 ]BRD4 orchestrates the metabolic-epigenetic regulation of GM-CSF expression and secretion to drive PD-L1⁺ macrophage-mediated immune evasion in triple-negative breast cancer

[ 27 ]Anlotinib enhances the antitumor immunity of radiotherapy by activating cGAS/STING in non-small cell lung cancer

[ 28 ]Overabundance of Veillonella parvula promotes intestinal inflammation by activating macrophages via LPS-TLR4 pathway

[ 29 ]Hydrogen sulfide maintains nitric oxide homeostasis through PpWRKY33-PpNR and PpGSNOR to enhance cold tolerance of peach fruit

[ 30 ]Discovery and evaluation of phenacrylanilide derivatives as novel potential anti-liver fibrosis agents

[ 31 ]Evaluation of a strain Long human respiratory syncytial virus with M2–2 gene deletion in intranasally vaccinated BALB/c mice

[ 32 ]FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression

[ 33 ]Isosteviol Sodium Exerts Anti-Colitic Effects on BALB/c Mice with Dextran Sodium Sulfate-Induced Colitis Through Metabolic Reprogramming and Immune Response Modulation

[ 34 ]The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development

[ 35 ]Effects of Lysophosphatidylcholine on Intestinal Health of Turbot Fed High-Lipid Diets

[ 36 ]YAP1 silencing enhances cisplatin efficacy in lung adenocarcinoma via activating mitochondrial apoptosis

[ 37 ]Tongxie-Yaofang formula regulated macrophage polarization to ameliorate DSS-induced colitis via NF-κB/NLRP3 signaling pathway

[ 38 ]Effect of cold atmospheric plasma on the gray mold rot of postharvest mulberry fruit

[ 39 ]Mediator complex subunit 8 promotes bladder cancer progression via Stearoyl-CoA desaturase

[ 40 ]Hepatocyte Growth Factor Overexpression Slows the Progression of 4NQO-Induced Oral Tumorigenesis

[ 41 ]Anti-Inflammation and Anti-Pyroptosis Activities of Mangiferin via Suppressing NF-κB/NLRP3/GSDMD Signaling Cascades

[ 42 ]ITGAL as a Prognostic Biomarker Correlated With Immune Infiltrates in Gastric Cancer.

[ 43 ]Mucus-penetrating lipid nanoparticles overcome lung barriers for pulmonary co-delivery of siGSDMD and pDNA-SAP in idiopathic pulmonary fibrosis

[ 44 ]Electroacupuncture modulates gut-lung microbiota and lung EMT to attenuate airway remodeling in COPD

[ 45 ]Single-Cell Transcriptome Comparison of Bladder Cancer Reveals Its Ecosystem.

[ 46 ]High Levels of DEAH-Box Helicases Relate to Poor Prognosis and Reduction of DHX9 Improves Radiosensitivity of Hepatocellular Carcinoma

[ 47 ]Baicalein inhibits the polarization of microglia/macrophages to the M1 phenotype by targeting STAT1 in EAE mice

[ 48 ]Unveiling the TrkA-p35/CDK5 axis: a novel therapeutic target in diabetic kidney disease

[ 49 ]Targeted knockdown of hepatic XDH via GalNAc-siRNA alleviates hyperuricaemia and renal injury in UOX−/− mice

[ 50 ]Mitochondria transfer from myocytes to endothelial cells Promotes angiogenesis in skeletal muscle

[ 51 ]Dual-specificity phosphatase 26-dificient neurons are susceptible to oxygen-glucose deprivation/reoxygenation-evoked apoptosis and proinflammatory response by affecting the TAK1-medaited JNK/P38 MAPK pathway

[ 52 ]Metabolomics-based discovery of XHP as a CYP3A4 inhibitor against pancreatic cancer

[ 53 ]Transcriptomic analysis reveals that the anti-PCOS effects of Zishen Qingre Lishi Huayu recipe may involve pathways and genes related to autophagy, steroidogenesis, oxidative stress, and inflammation in granulosa cells

[ 54 ]Transcriptomic analysis reveals the critical role and mechanisms of Shenxian zhou in preventing age-related cognitive impairment

[ 55 ]Design, synthesis and biological evaluation of coumarin derivatives as potential BRD4 inhibitors

[ 56 ]Systematic evaluation of TCGA tumor microbiota reveals context-dependent reliability

[ 57 ]Electrochemical sensor analyzing ANGPTL4 promotes M2 polarization of lung adenocarcinoma tumor-associated macrophages: inhibiting ferroptosis through the NF-κB-induced SLC7A11 transcription

[ 58 ]Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress

[ 59 ]1H-Indazoles derivatives targeting PI3K/AKT/mTOR pathway: Synthesis, anti-tumor effect and molecular mechanism

[ 60 ]Hepatocyte specific Rab27a knockout aggravates metabolic dysfunction associated fatty liver disease

[ 61 ]Transdermal delivery of Protocatechuic aldehyde using hyaluronic acid/gelatin-based microneedles for the prevention and treatment of hypertrophic scars

[ 62 ]Recognition of Glycometabolism-Associated lncRNAs as Prognosis Markers for Bladder Cancer by an Innovative Prediction Model

[ 63 ]YB1 participated in regulating mitochondrial activity through RNA replacement

[ 64 ]Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9

[ 65 ]Organic copper promoted copper accumulation and transport, enhanced low temperature tolerance and physiological health of white shrimp (Litopenaeus vannamei Boone, 1931)

[ 66 ]Butyrate ameliorates doxorubicin-induced heart failure by inhibiting cardiomyocyte ferroptosis through gut-heart axis

[ 67 ]Robust single-molecule tracking of RNA abundance and dynamics via TSSOT

[ 68 ]Bai-Hu-Tang regulates endothelin-1 and its signalling pathway in vascular endothelial cells

[ 69 ]Shionone Alleviates Sepsis-Induced Acute Lung Injury by Regulating Macrophage Polarization Through the HMGB1/NF-κB Pathway

[ 70 ]Histone H2B-associated proteins: the Arabidopsis nucleolin 1 binds H2B and facilitates nucleosome disassembly via RNA-dependent mechanism

[ 71 ]Establishment and application of a detection method for chinese rice-field eels rhabdovirus (CrERV) using the RPA-CRISPR/Cas12a System

[ 72 ]Gut microbiota and metabolomic alterations underlying the therapeutic effects of SQJZ capsules in a rat model of chronic renal failure

[ 73 ]Porphyromonas gingivalis promotes oral squamous cell carcinoma progression via the IL-6/EZH2/Snai2 axis

[ 74 ]LncRNA GAS5 inhibits the remodeling of the tumor microenvironment by binding to miR-93-5p, thereby suppressing the development of osteosarcoma

[ 75 ]Evaluation of the effects of dietary mycotoxin-degrading adsorbent on juvenile turbot (Scophthalmus maximus L.) fed aflatoxin B1-contaminated diets

[ 76 ]Silicate Ions Derived from Calcium Silicate Extract Decelerate Ang II-Induced Cardiac Remodeling

[ 77 ]The evaluation of tumor microenvironment infiltration and the identification of angiogenesis-related subgroups in skin cutaneous melanoma

[ 78 ]Comprehensive Analysis of Purine-Metabolism-Related Gene Signature for Predicting Ovarian Cancer Prognosis, Immune Landscape, and Potential Treatment Options

[ 79 ]Tunable Toxicity of Bufadienolides is Regulated through a Configuration Inversion Catalyzed by a Short-Chain Dehydrogenase/Reductase

[ 80 ]Strain-specific immune response patterns to Borrelia burgdorferi infection: a comparative transcriptomic analysis in C3H and C57BL/6 mice

[ 81 ]OI inhibits development of ovarian cancer by blocking crosstalk between cancer cells and macrophages via HIF-1α pathway

[ 82 ]Moderate-Intensity Intermittent Training Alters the DNA Methylation Pattern of PDE4D Gene in Hippocampus to Improve the Ability of Spatial Learning and Memory in Aging Rats Reduced by D-Galactose

[ 83 ]Linoleic acid ameliorates intestinal mucosal barrier injury in early weaned pigeon squabs (Columba livia)

[ 84 ]Identifying miRNAs Associated with the Progression of Keloid through mRNA-miRNA Network Analysis and Validating the Targets of miR-29a-3p in Keloid Fibroblasts

[ 85 ]DEHP Exposure Affects Mitochondrial Function During Ovarian Follicle Development

[ 86 ]GTPBP4 promotes colorectal cancer cell proliferation by positively regulating MYC-driven glycolytic metabolism

[ 87 ]RNA Interference Targeting MaCht-2 Induces Severe Molting Defects and Lethality in Monochamus alternatus

[ 88 ]Unraveling the Mechanism of Tangmaikang Granules in Treating Diabetic Kidney Disease Based On UPLC-MS/MS, Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation

[ 89 ]RNA-seq reveals Nup62 as a potential regulator for cell division after traumatic brain injury in mice hippocampus

[ 90 ]Isoliquiritigenin combined with gemcitabine inhibited lung cancer by suppressing JAK2/STAT3 signaling via lncRNA-p21/miRNA-4534 axis

[ 91 ]Multi-omic profiling reveals SMAD4 drives linoleic acid-arachidonic acid metabolism to mediate PDAC radiosensitivity via the SLC27A3/FADS2 axis

[ 92 ]LncRNA HCG11 Accelerates Atherosclerosis via Regulating the miR-224-3p/JAK1 Axis

[ 93 ]Glycolytic reprogramming in host response to Borrelia burgdorferi: A gene signature revealed by integrative bioinformatics analysis and machine learning

[ 94 ]Expression and functional analysis of Niemann–Pick C2 gene in Phytoseiulus persimilis

[ 95 ]lncRNA DLGAP1-AS2 Modulates the TGF-β/Smad Signaling Pathway to Regulate Epithelial-Mesenchymal Transition in Renal Cell Carcinoma

[ 96 ]Tubacin Decelerates TGF-β1-Induced Pro-Fibrotic Effects on Human Dermal Fibroblasts by Regulating HDAC6-Mediated Deacetylation of α-Tubulin and Hsp90