Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.

推荐稀释比 FC:1/50-1/100

Flow Cytometry analysis of PBMC stained with CD154 antibody(Red).Blue line histogram represents nonspecific negative control

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.