The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

Western

Western blot analysis of GPNMB in PANC-1 and PC-3 lysates using GPNMB antibody.

Immunohistochemical

Immunohistochemical analysis of paraffin-embedded Human tonsils using GPNMB antibody, with DAB staining.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded esophagus cancer tissues using GPNMB antibody with DAB staining.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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