This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer.

Western

Western blot analysis of TTF1 in 293 lysates using Thyroid Transcription Factor 1 antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human thyroid using TTF1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunofluorescence

Immunofluorescence analysis of Thyroid Transcription Factor 1 in Hela using TTF1 antibody.