分子生物学
IVD分子诊断
细胞培养与分析
蛋白研究
细胞因子
重组蛋白
抗体
高通量测序建库
病原检测UCF系列
生物医药
工具酶
抑制剂激活剂与常用试剂
仪器
耗材

Mechanical and biological properties of enhanced porous scaffolds based on triply periodic minimal surfaces

Sijia Zou, Yanru Mu, Bingchu Pan, Guangyong Li, Lei Shao, Jianke Du, Yuan Jin

Journal:MATERIALS & DESIGN

IF:9.42

DOI:10.1016/j.matdes.2022.110803

PMID:

Published:2022-05-31

research field:分子生物学毒理学生殖生物学环境健康生态毒理学

Abstract

Triply periodic minimal surfaces (TPMS) - based porous structures have been universally adopted for mimicking the properties of bone scaffolds due to their interconnected geometries with smooth surfaces and controllable pores. To further increase the versatility and controllability, an enhanced porous scaffold based on TPMS is proposed. The enhanced pores with different sizes are designed onto three types of TPMS-based scaffolds and then additively manufactured through laser powder bed fusion (LPBF). To investigate the manufacturability, various approaches are used and the results confirm that morphological features of printed samples are identical to the designed ones. As for mechanical properties, the results from the compression tests show that the elastic modulus and compressive strength of enhanced porous scaffolds are 2.0 GPa to 5.1 GPa and 86.7 MPa to 264.2 MPa respectively, which are all in the range of human bones. In terms of permeability, both experiments and simulation indicate that the designed scaffolds have 40%−150% improvement compared to scaffolds without enhanced pores. The biocompatibility of the scaffolds is further verified by in vitro studies. The results demonstrate the suitability of the proposed enhanced porous scaffolds for bone implants, and it will facilitate the design of more effective porous materials.

本文使用的Yeasen产品

购物车
客服
转染试用