Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy
Zhang Zhicheng, Ding Yawen, Li Jinbiao, Wang Li, Xin Xiaoyan, Yan Jing, Wu Jinhui, Yuan Ahu, Hu Yiqiao
Journal：Nano Research
IF：8.18
DOI：10.1007/s12274-020-3241-7
PMID：
Published：2020-12-29
research field：细胞生物学纳米技术癌症治疗材料科学
Abstract
Ferroptosis is a newly form of regulated cell death, which has attracted great attention for tumor therapy. Herein, we prepared nanoscale coordination polymer Fe-NQA particles to deliver iron and NQA (vitamin K 3 derivative) into tumor cells, which synergistically promoted ferroptotic therapy for inhibiting tumor growth, preventing metastasis, and overcoming radioresistance.
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