Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.; (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus.

高纯度、高活性、低内毒素、高批间一致性

          Western Blot

The protein is detected by Mouse anti-6*His monoclonal antibody.

               Activity

Measured by its binding ability in a functional ELISA. Immobilized Human CLDN1 at 10 μg/ml can bind Anti-CLDN1 recombinant antibody . The EC₅₀ is 35.03-50.71 ng/mL. The VLPs  is negative control.

             SEC-HPLC

The purity of VLPs was greater than 95% as determined by SEC-HPLC

-25 ~ -15℃保存，收到货之后有效期1年。避免反复冻融，打开小瓶前先离心。建议等分分装为一次实验使用量，分装后，-20℃冻存。