Generation of a human induced pluripotent stem cell line (JSPHi003-A) from a patient with atrial fibrillation and ventricular tachycardia carrying LMNA frame shift mutation (c.1304_1307dup)
Zhiqiao Lin, Hongyi Cheng, Yike Zhang, Bingyu Zheng, Feng Zhang, Yongping Lin, Yue Zhu, Weizhu Ju, Chang Cui, Minglong Chen
Journal：Stem Cell Research
IF：1.59
DOI：10.1016/j.scr.2022.102909
PMID：36095892
Published：2022-09-07
research field：分子生物学基因治疗生物药剂学药物递送纳米医学
Abstract
The iPSC line was generated from the peripheral blood mononuclear cells (PBMCs) from a 53-year-old female patient carrying the LMNA gene mutation (c.1304_1307dup) diagnosed with atrial fibrillation and paroxysmal ventricular tachycardia. Through comprehensive detection, it was verified that the cell line had the LMNA gene mutation, normal karyotype, and the potential to differentiate into the three germ layers. This cell line may reveal potential therapeutic targets for atrial and ventricular arrhythmias caused by LMNA mutations.
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