CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can bind to CD152 as well, also known as CTLA-4, to deliver an inhibitory signal to T cells.

推荐稀释比 FC:5μL per test for million cells or whole blood in 100 μL volume.

Flow cytometry analysis of Daudi cell line stained with CD86 antibody（4D8H6PE）.mouse IgG1 (dotted line) is the isotype.

Store at 2-8℃ and protected from prolonged exposure to light. Avoid freeze/thaw cycles.