On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity).

Western

Western blot analysis of Leptin Receptor in 293T lysates using Leptin Receptor antibody

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human tonsil using Leptin Receptor antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.