IL-36 gamma [previously called IL-1F9, IL-1 epsilon (epsilon), and IL-1H1] is a member of the IL-1 family which includes IL beta, IL alpha, ILra, IL8, IL36 Ra (ILF5), IL-36 alpha (IL1F6), IL36 beta (IL1F8), IL37 (IL?1F7) and IL-1F10. All family members show a 12 beta ?strand, beta ?trefoil configuration, and are believed to have arisen from a common ancestral gene. IL36 gamma is an 18?22 kDa, 169 amino acid intracellular and secreted protein that contains no signal sequence, no prosegment and no potential N?linked glycosylation sites. Human IL?36 gamma (aa 18?169) shares 58%, 59%, 68% and 69% aa sequence identity with mouse, rat, bovine and equine IL36 gamma, respectively, and 23?57% aa sequence identity with other family members. 134 aa isoform missing aa 19?53 has been reported. Highest levels of IL?36 gamma are produced by Langerhans cells, keratinocytes, and stomach Chief cells and parietal cells; these cells contribute to firstline defense against pathogens in the skin, lungs and digestive tract. Its expression is induced by LPS treatment of monocytes, and by IL? alpha / beta, IL?17 or TNF? alpha treatment of keratinocytes and bronchial epithelia. Skin IL-36 gamma expression is increased in contact hypersensitivity and psoriasis. It is elevated in inflammatory disorders of the lung (such as asthma) and viral infections. Lung IL?36 gamma and other IL?36 proteins contribute to neutrophil influx. The receptor for IL-36 gamma is a combination of IL Rrp2, mainly found in epithelia and keratinocytes, and the widely expressed IL?1 RAcP. IL?36 alpha,beta and gamma all activate NF? kappa B and MAPK pathways in an IL?1 Rrp2 dependent manner, and IL?36 gamma induces production of inflammatory cytokines and chemokines such as CXCL8/IL?8.

高纯度、高活性、低内毒素、高批间一致性

-25 ~ -15℃保存，收到货之后有效期1年。 复溶后，无菌条件下，2~8℃保存，7天有效期。复溶后， 无菌条件下，-85 ~ -65℃保存，3个月有效期。