IL36 alpha, previously called ILF6 and FIL1 epsilon  (family of IL?1 member epsilon), is a member of the IL?1 family which includes IL beta, IL alpha, ILra, IL8, and novel family members IL36 Ra (ILF5), IL36 beta (IL?1F8), IL36 gamma (ILF9), IL?37 (IL?1F7) and IL?1F10. All family members show a 12 beta strand, beta trefoil configuration, and are believed to have arisen from a common ancestral gene. IL?36 alpha is an 18 kDa, 160 amino acid (aa) intracellular and secreted protein that contains no signal sequence, no prosegment and no potential N?linked glycosylation sites. It can be externalized nonspecifically in response to LPS and ATPinduced activation of the P2X7 receptor. Fulllength recombinant IL?36 alpha is less active than endogenous IL36 alpha, but trimming of the N?termini enhances its activity. Mouse IL?36 alpha shares 83% aa sequence identity with rat IL?36 alpha, 5460% with human, rabbit, equine and bovine IL36 alpha, and 2757% aa sequence identity with other novel IL family members. IL36 alpha is mainly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine. It is expressed by monocytes, B and T cells. The receptor for IL36 alpha is a combination of IL Rrp2 (also called IL RL2 or IL?1 R6), mainly found in epithelia and keratinocytes, and the widely expressed IL?1 RAcP. IL?36 alpha, beta and gamma all activate NF? kappa B and MAPK pathways in an IL?1 Rrp2 dependent manner, and induce production of inflammatory cytokines and chemokines such as CXCL8/IL?8. IL?36 alpha and other family members are overexpressed in psoriatic skin lesions, and transgenic overexpression of IL?36 alpha in skin keratinocytes produces epidermal hyperplasia. IL?36 alpha is present in kidney tubule epithelia; it is highly overexpressed in tubulointerstitial lesions in mouse models of chronic glomerulonephritis, lupus nephritis and diabetic nephritis. IL?36 alpha is induced by inflammation in adipose tissue?resident alternately activated (M2) macrophages, and reduces adipocyte differentiation.

高纯度、高活性、低内毒素、高批间一致性

-25 ~ -15℃保存，收到货之后有效期1年。 复溶后，无菌条件下，2~8℃保存，7天有效期。复溶后， 无菌条件下，-85 ~ -65℃保存，3个月有效期。