4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane protein domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Recombinant Human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues.

 

产品性质

Synonyms	41BB Ligand; 4-1BB Ligand; 4-1BBL; CD137L; TNFSF9
Uniprot No.	P41273
Source	Recombinant Biotinylated Human 4-1BB Ligand/TNFSF9 Trimer Protein is expressed from HEK293 Cells with monomeric hFc tag at the N-terminal. It contains Arg71-Glu254.
Molecular Weight	The protein has a predicted MW of 84.3 kDa same as Tris-Bis PAGE result.
Physical Appearance	Liquid Solution
Purity	> 95% as determined by SDS-PAGE and HPLC
Endotoxin	< 1.0 EU per 1μg of the protein by the LAL method.
Formulation	Supplied as 0.22μm filtered solution in PBS (pH 7.4).

 

运输与保存方法

The products are shipped with ice pack and can be stored at -80°C for 1 year.

Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles.

 

注意事项

1. For your safety and health, please wear lab coats and disposable gloves for operation.
2. For research use only!