Catharanthine ((+)-3,4-Didehydrocoronaridine),又称长春质碱或泻花碱,是一种从长春花中分离出来的生物碱,能抑制纺锤体的形成、核糖核酸和脂肪合成,具有抗肿瘤和降压的作用。
参考文献
[1] Pereira DM, et al. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine. 2010 Jul;17(8-9):646-52.
[2] Prakash V, et al. Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline. Biochemistry. 1991 Jan 22;30(3):873-80.
[3] Jadhav A, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345(3):383-92.
冰袋运输。粉末直接保存于-25~-15℃,有效期3年。建议溶解分装后于-25~-15℃干燥保存,避免反复冻融。