Skepinone-L (CBS3830)是ATP竞争性的p38 MAPK选择性抑制剂，IC₅₀为5 nM。Skepinone-L对依赖于p38 MAPK通路的HSP27 Ser82的磷酸化作用表现出浓度依赖性抑制，并且也能降低p38 MAPK调节的下游因子，如TNF-α、IL-1β和IL-10。

参考文献

[1] Koeberle SC, et al. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nat Chem Biol. 2011 Dec 25;8(2):141-3.

[2] Borst O, et al. Skepinone-L, a novel potent and highly selective inhibitor of p38 MAP kinase, effectively impairs platelet activation and thrombus formation. Cell Physiol Biochem. 2013;31(6):914-24.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。