Neflamapimod (VX-745, VX745)是p38α MAPK选择性抑制剂，IC₅₀为10 nM，可穿过血脑屏障，表现出抗炎活性，对p38γ MAPK和其它激酶没有作用。VX-745也能抑制p38β MAPK，IC₅₀为220 nM。

参考文献

[1] Duffy JP, et al. The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor. ACS Med Chem Lett. 2011 Jul 28;2(10):758-63.

[2] Haddad JJ. VX-745. Vertex Pharmaceuticals. Curr Opin Investig Drugs. 2001 Aug;2(8):1070-6.

[3] Alam JJ. Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats. J Alzheimers Dis. 2015;48(1):219-27.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。