GW5074 (GW-5074)是c-Raf选择性抑制剂，IC₅₀为9 nM，阻碍c-Raf Ser259的磷酸化。GW5074在神经退行性疾病具有潜力，在亨廷顿氏舞蹈病模型中表现出神经保护作用。

参考文献

[1] Chin PC, et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem. 2004 Aug;90(3):595-608.

[2] Lei Y, et al. The Raf-1 inhibitor GW5074 and NSC 34521 suppress sidestream smoke-induced airway hyperresponsiveness in mice. Respir Res. 2008 Nov 3;9(1):71.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。