Parthenolide ((-)-Parthenolide)，又称小白菊内酯或欧苷菊，是来源于药草短舌匹菊的倍半萜内酯，是NF-κB抑制剂，表现出抗炎、抗肿瘤和抗病毒活性。它传统上主要用来治疗发热、偏头痛、皮肤感染和类风湿性关节炎。Parthenolide还可不依赖NF-κB特异性抑制HDAC1，而不影响其他I/II类HDACs。

参考文献

1. Zhao X, et al. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014 Jan 6;33:3.
2. Barbier-Torres L, et al. Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1. Hepatology. 2015 Oct;62(4):1237-48.
3. Nakshatri H, et al. NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death Dis. 2015 Jan 22;6:e1608.

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