Niclosamide(NSC 178296/BAY2353)氯硝柳胺 STAT3抑制剂|CAS 50-65-7（53025ES）

Niclosamide (BAY2353, BAY-2353, Niclocide, NSC 178296, NSC178296)，又称氯硝柳胺、灭绦灵、贝螺杀或杀螺胺，是一种驱虫药，能抑制DNA复制，也是STAT3抑制剂(IC₅₀: 0.7 μM)，但不抑制其他STAT家族成员的激活。

参考文献

1.Ren, X, et al., Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway. ACS Medicinal Chemistry Letters. 2010;1(9):454-459.

2.Wu CJ, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004;48(7):2693-6.

3.Chen, M, et al., The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry. 2009;48(43):10267-7.

3.Jin Y, et al. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res. 2010;70(6): 2516-27.

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