Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.

Western

Western blot analysis of LDLR in HepG2 lysates using LDL Receptor antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded rat testis using LDL Receptor antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.