(-)-Epicatechin可抑制环加氧酶-1 (COX-1),并通过阻断NF-κB p65亚基的核定位来抑制IL-1β诱导的iNOS表达。
|
英文别名 (English Synonym) |
(-)-epicatechin |
|
中文名称 (Chinese Name) |
表儿茶素 |
|
靶点 (Target) |
PKC |
|
通路 (Pathway) |
TGF-β/Smad |
|
CAS号 (CAS NO.) |
490-46-0 |
|
分子式 (Formula) |
C15H14O6 |
|
分子量 (Molecular Weight) |
290.27 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Shay J, Elbaz HA, Lee I, Zielske SP, Malek MH, Hüttemann M. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015,2015:181260. doi: 10.1155/2015/181260. Epub 2015 Jun 9. PMID: 26180580, PMCID: PMC4477097.[2]Nogueira L, Ramirez-Sanchez I, Perkins GA, Murphy A, Taub PR, Ceballos G, Villarreal FJ, Hogan MC, Malek MH. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15,589(Pt 18):4615-31. doi: 10.1113/jphysiol.2011.209924. Epub 2011 Jul 25. PMID: 21788351, PMCID: PMC3208228.
