IWP-2(IWP2) Porcn抑制剂 Wnt信号通路抑制剂|CAS 686770-61-6（53013ES）

IWP-2 (IWP2)是Wnt分泌和加工的抑制剂，IC₅₀值为27 nM，作用于Porcn使其失活，选择性地抑制Porcn介导的Wnt棕榈酰化。IWP-2抑制R1胚胎干细胞的自我更新，并促进hPSC分化为心肌细胞，被广泛用于再生医学和肿瘤研究。

参考文献

[1] Huang Y, et al. IWP2 impairs the development of porcine somatic cell nuclear transfer embryos via Wnt signaling pathway inactivation. Biomed Rep. 2017 Jul;7(1):36-40.

[2] Chen D, et al. Paracrine factors from adipose-mesenchymal stem cells enhance metastatic capacity through Wnt signaling pathway in a colon cancer cell co-culture model. Cancer Cell Int. 2015 Apr 18;15:42.

[3] García-Reyes B, et al. Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. J Med Chem. 2018 May 10;61(9):4087-4102.

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