[ 1 ]VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes

[ 2 ]Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

[ 3 ]Bioinspired, Mitochondria-Targeted Single-Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism​

[ 4 ]A bio-live intraosseous battery for bone-nerve repair

[ 5 ]Time-of-Day Defines the Risk of Thermally Abused Frying Oil to Renal Injury by Modulating the Diurnal Dynamics of Oxylipins

[ 6 ]Control of a sap-sucking insect pest by plastid-mediated RNA interference

[ 7 ]Metformin attenuated sepsis-related liver injury by modulating gut microbiota

[ 8 ]Immuno-Training Remodeled Vascular Microenvironment via Peptide-Functionalized Hydrogel Microspheres for Neural Repair

[ 9 ]Identification of a Bioactive Domain in Type II Collagen That Promotes Bone Repair via EGFR Signaling

[ 10 ]Anti-alcoholism drug disulfiram for targeting glioma energy metabolism using BBB-penetrating delivery of fixed-dose combination

[ 11 ]A non-enzymatic function of neuraminidase 1 restrains hepatic glucagon response in mice

[ 12 ]Engineered dCas12f1-SAM enables robust transcriptional activation and gain-of-function screening in primary human cells

[ 13 ]MYC-induced USP10 stabilizes SOX4 to promote thymocyte proliferation and leukemia onset in mice

[ 14 ]Viral Protein-Pseudotyped and siRNA-Electroporated Extracellular Vesicles for Cancer Immunotherapy

[ 15 ]Mesopore Controls the Responses of Blood Clot-Immune Complex via Modulating Fibrin Network

[ 16 ]Discovery of Novel GR Ligands toward Druggable GR Antagonist Conformations Identified by MD Simulations and Markov State Model Analysis

[ 17 ]CeO2 nanohybrid as a synergist for insecticide resistance management

[ 18 ]DNA Framework-Encoded Digital Recorder for Bacterial Discrimination

[ 19 ]In Situ Redox-Omics Decoding of Nanoparticle–Protein Corona Interactions Drives the Mitochondrial Metabolic-Immunological Mechanism in Microglia

[ 20 ]Treg-γδ T cell axis determines sexual dimorphism in hepatocarcinogenesis

[ 21 ]Collaborative Design of MgO/FeOx Nanosheets on Titanium: Combining Therapy with Regeneration

[ 22 ]A Dual-Cross-Linked Hydrogel Patch for Promoting Diabetic Wound Healing

[ 23 ]Prussian blue analogue-mineralized ginseng-derived vesicles promote PPARγ nuclear translocation to suppress tumor vasculogenic mimicry and reverse the immunosuppressive microenvironment

[ 24 ]Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy

[ 25 ]Tumor-enriched circRNA TAFCR1 drives cancer progression and metastasis by disrupting UBE1-dependent TRIM21-mediated CD44 ubiquitination

[ 26 ]Novel circUnc79 regulates morphine-induced reward memory via the miR-149-3p/EAAT2 axis and glutamatergic plasticity

[ 27 ]Discovery of a potent covalent inhibitor for the treatment of sepsis targeting DNAJC9: Identification of a druggable target for inflammation

[ 28 ]Fusobacterium nucleatum-mediated tryptophan metabolic reprogramming facilitates immunosuppression and metastasis in triple-negative breast cancer

[ 29 ]Biomimetic Ti–6Al–4V alloy/gelatin methacrylate hybrid scaffold with enhanced osteogenic and angiogenic capabilities for large bone defect restoration

[ 30 ]Enhanced osteogenesis of titanium with nano-Mg(OH)2 film and a mechanism study via whole genome expression analysis

[ 31 ]Zn/Sr dual ions-collagen co-assembly hydroxyapatite enhances bone regeneration through procedural osteo-immunomodulation and osteogenesis

[ 32 ]Phocaeicola coprophilus-Derived 6-Methyluracil Attenuates Radiation-Induced Intestinal Fibrosis by Suppressing the IDO1-Kynurenine-AHR Axis

[ 33 ]N4-acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

[ 34 ]Promoter Hypermethylation-Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5-Mediated Wnt/β-Catenin Pathway Activation

[ 35 ]Super-Enhancer-Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

[ 36 ]SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis

[ 37 ]Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1-Mediated M1 Macrophage Polarization in Sarcoidosis

[ 38 ]Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

[ 39 ]Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

[ 40 ]GSDME acts as an epigenetic modifier to promote melanoma development via centriole biogenesis regulator PLK4

[ 41 ]Super-enhancer-driven TCF4 orchestrates neuroblastoma metastasis by sphingolipid-dependent membrane remodeling and ITGB1-FAK activation

[ 42 ]Perfluorooctanoic acid (PFOA) exposure affects early embryonic development and offspring oocyte quality via inducing mitochondrial dysfunction

[ 43 ]Targeted manipulation of grain shape genes effectively improves outcrossing rate and hybrid seed production in rice

[ 44 ]Carrier-free dual-drug nanoplatforms cooperatively remodel macrophage and VSMC fate specifications for treating abdominal aortic aneurysm

[ 45 ]Structure elucidation of duckweed polysaccharide from Spirodela oligorrhiza and its anti-inflammatory activity

[ 46 ]Bimetallic MOF-engineered 3D-printed PEEK implants orchestrate osteoregeneration via macrophage reprogramming

[ 47 ]Identification of a metabolic–immune crosstalk in Still’s disease: monocyte/macrophage-derived immunometabolite itaconate dictates hepatic immunopathology via the CXCL10–CD8 T cell axis

[ 48 ]An epigenetically enhanced whole-cell vaccine in a stimulatory hydrogel for robust antitumor immunity

[ 49 ]Therapeutic translation of traditional Chinese medicine Huangqi derived exosome like nanoparticles: targeting prostate cancer through ferroptosis activation, immune reprogramming, and microbiome modulation

[ 50 ]R-loop processing via REXO4-RNaseH1–mediated endo- and exo-cleavage coupling mode prevents genome instability and antitumor immunity

[ 51 ]CD44/TRPV1 dual-targeted nanocarrier enables drug retention and multidimensional therapy for inflammatory skin diseases

[ 52 ]A novel mRNA nanovaccine with dual immunoregulation ameliorates rheumatoid arthritis and associated pneumonia

[ 53 ]Competitive Binding of UBA52 and HOPX Modulates β-catenin Stability in Colorectal Cancer in the Context of High-Iron Intake

[ 54 ]The CdFBX1-CdMYB26-CdMYB5 module regulates ion homeostasis under salt stress by fine-tuning CdSOS1 expression in bermudagrass

[ 55 ]Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I

[ 56 ]Magnetism-mediated targeting hyperthermia-immunotherapy in “cold” tumor with CSF1R inhibitor

[ 57 ]HBx represses WDR77 to enhance HBV replication by DDB1-mediated WDR77 degradation in the liver

[ 58 ]Lactate-induced miR-7-5p/TRIM33 Reprograms Metabolic Flux to Suppress Tumor Growth and Viral Reactivation

[ 59 ]Bilobalide attenuates Salmonella typhimurium virulence by repressing the quorum sensing and Type III secretion system effectors

[ 60 ]A dual functional Ti-Ga alloy: inhibiting biofilm formation and osteoclastogenesis differentiation via disturbing iron metabolism

[ 61 ]Genipin induces liver injury by disrupting the CPS1-regulated urea cycle and redox homeostasis

[ 62 ]Epigenetic activation of the elongator complex sensitizes gallbladder cancer to gemcitabine therapy

[ 63 ]Complementary and Synergistic Design of Bi-Layered Double Hydroxides Modified Magnesium Alloy toward Multifunctional Orthopedic Implants

[ 64 ]MRI-guided diagnosis and dual-pathway neuroprotection in ischemic stroke via PDA-engineered apple exosome-like nanoparticles

[ 65 ]Strategy Based on Liquid Crystal Elastomer Active Tensile to Accelerate Bone Repair: Mechanistic Analysis of LAMB1-ITGB4 Mediated PI3K-AKT Signaling

[ 66 ]Hyaluronic Acid-Based Injectable Dual-Network Hydrogel for 6′-Sialyllactose Mimetic Peptide Delivery and Microenvironment Reconstruction in Brachial Plexus Root Avulsion

[ 67 ]p53 directly downregulates the expression of CDC20 to exert anti-tumor activity in mantle cell lymphoma

[ 68 ]The AGPS regulatory variant rs113671272 confers esophageal squamous cell carcinoma susceptibility through allele-specific MEIS3 binding and NF-κB activation in Chinese populations

[ 69 ]Arsenic retention in erythrocytes and excessive erythrophagocytosis is related to low selenium status by impaired redox homeostasis

[ 70 ]Synergistic physiological and transcriptomic profiling deciphers an early coordinated defense network driving aluminum tolerance in sorghum (Sorghum bicolor L.)

[ 71 ]Congener-resolved hazard identification of ginkgolic acids as emerging natural contaminants

[ 72 ]Physiological and transcriptomic changes of zebrafish (Danio rerio) embryos-larvae in response to 2-MIB exposure

[ 73 ]DcH3.3 and DcNAC1 Regulate the Expression of UGT73A93 Involved in the Changes in Flower Colour and Fungal Resistance in Carnation

[ 74 ]Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation

[ 75 ]Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy

[ 76 ]Intracellular LRG1 recruits MARCH2 to ubiquitinate and degrade endothelial VE-cadherin in septic lung injury

[ 77 ]CCS facilitates the progression of ovarian cancer by suppressing ferroptotic cell death via the modulation of p53-mediated expression of SLC7A11 and GPX4

[ 78 ]Targeting the mechanics-glycolysis-histone lactylation axis to rescue bone regeneration under insufficient mechanical stimulation

[ 79 ]“Gingival Soft Tissue Integrative” Lithium Disilicate Glass-Ceramics with High Mechanical Properties and Sustained-Release Lithium Ions

[ 80 ]CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma: a cross-talk between FGF21 and the NRF2 pathway

[ 81 ]Intraocular delivery of ZIF-90-RhB-GW2580 nanoparticles prevents the progression of photoreceptor degeneration

[ 82 ]ZmSPL10/14/26 are required for epidermal hair cell fate specification on maize leaf

[ 83 ]A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis

[ 84 ]CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation

[ 85 ]ZC3H15 promotes glioblastoma progression through regulating EGFR stability

[ 86 ]Malic enzyme 1 contributes to tumorigenesis and lenvatinib resistance in hepatocellular carcinoma via FSP1-dependent ferroptosis evasion

[ 87 ]M2 macrophages promote lymphatic metastasis by regulating PKM2 nuclear translocation in triple-negative breast cancer

[ 88 ]Zinc-Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

[ 89 ]Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster

[ 90 ]The sustained PGE2 release matrix improves neovascularization and skeletal muscle regeneration in a hindlimb ischemia model

[ 91 ]Effects of citronellol grafted chitosan oligosaccharide derivatives on regulating anti-inflammatory activity

[ 92 ]CRISPR-Cas13a cascade-based viral RNA assay for detecting SARS-CoV-2 and its mutations in clinical samples

[ 93 ]Recombinant cell-penetrating trichosanthin synergizes anti-PD-1 therapy in colorectal tumor

[ 94 ]Deubiquitinase OTULIN dampens RIG-I-dependent antiviral signaling by removing linear ubiquitination from TRAF6

[ 95 ]Nitrospira-Driven partial Denitrification: Kinetics, Mechanisms, and synergistic potential with anammox

[ 96 ]STING-STAT1-ZBP1 axis orchestrates PANoptotic signaling in ischemia-reperfusion induced acute kidney injury

[ 97 ]DLD, upregulated by YY1, fuels glioblastoma multiforme progression via EphA2 phosphorylation to activate PI3K/AKT/mTOR

[ 98 ]hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3

[ 99 ]Functional Attenuation of UCP1 as the Potential Mechanism for a Thickened Blubber Layer in Cetaceans

[ 100 ]Exploring the function of stromal cells in cholangiocarcinoma by three-dimensional bioprinting immune microenvironment model.