Loperamide hydrochloride (R-18553 hydrochloride, Loperamide HCl, ADL 2-1294)，又称盐酸洛哌丁胺或盐酸氯苯哌酰胺，是阿片受体(opioid receptor)激动剂，ED₅₀为0.15 mg/kg，具有止泻作用，调节和缓解与炎症性肠病相关的长期腹泻，用于治疗急、慢性痢疾。Loperamide hydrochloride也可用作肌肉松弛剂。

参考文献

1.D L DeHaven-Hudkins, et al. Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J Pharmacol Exp Ther. 1999 Apr;289(1):494-502.

2.Quinney S K, et al. Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. J Pharmacol Exp Ther. 2005 Jun;313(3):1011-6.

3.Church J, et al. Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons. Mol Pharmacol. 1994 Apr;45(4):747-57.

4.Menéndez L, et al. Analgesic effects of loperamide in bone cancer pain in mice. Pharmacol Biochem Behav. 2005 May;81(1):114-21.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。