[ 1 ]An SHR–SCR module specifies legume cortical cell fate to enable nodulation

[ 2 ]Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

[ 3 ]Timosaponin AIII enhances CAR-T cell potency and prevents relapse through impairing CAR-Tregs

[ 4 ]Regulation of Nucleotide Metabolism with Nutrient-Sensing Nanodrugs for Cancer Therapy

[ 5 ]A fluorinated peptide with high serum- and lipid-tolerence for the delivery of siRNA drugs to treat obesity and metabolic dysfunction

[ 6 ]Omega-based mini prime- and base-editing systems in Escherichia coli

[ 7 ]Nanoengineering of STING-IDO1 feedback machinery potentiates antitumor immunity

[ 8 ]Irisin ameliorates age-associated sarcopenia and metabolic dysfunction

[ 9 ]USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination

[ 10 ]Multi-omic profiling of plasma reveals molecular alterations in children with COVID-19

[ 11 ]Co-delivery of a STING agonist and indoleamine 2,3-dioxygenase 1 blockade activates type I dendritic cells in cancer

[ 12 ]miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways

[ 13 ]3D bioprinted autologous bone particle scaffolds for cranioplasty promote bone regeneration with both implanted and native BMSCs

[ 14 ]A Self-Assembling Nanomodulator for Synergistic Therapy of Intracerebral Hemorrhage

[ 15 ]UBE2O primes hepatocytes to restore immune tolerance in autoimmune hepatitis via inhibiting YBX1/IL-6 axis

[ 16 ]Oncogenic driver and therapeutic target: Prolactin signalling axis in retroperitoneal sarcoma

[ 17 ]Rhein Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting the Microglial NLRP3 Inflammasome/Pyroptosis Axis and Regulating Microglial M1/M2 Phenotypes

[ 18 ]Identification of a novel acylthiourea-based potent broad-spectrum inhibitor for enterovirus 3D polymerase in vitro and in vivo

[ 19 ]GCDCA promotes hepatocellular carcinoma progression through S1PR2/PI3K/AKT-mediated polarization of M2-type macrophages

[ 20 ]TNF-like weak inducer of apoptosis / nuclear factor κB axis feedback loop promotes spinal cord injury by inducing astrocyte activation

[ 21 ]A Model of Waardenburg Syndrome Using Patient-Derived iPSCs With a SOX10 Mutation Displays Compromised Maturation and Function of the Neural Crest That Involves Inner Ear Development

[ 22 ]IMB5023: Dual suppression of microtubule assembly and STAT3 signaling overcomes chemoresistance and activates antitumor immunity

[ 23 ]MOTS-c attenuates hyperoxia-induced neonatal cardiac injury by inhibiting oxeiptosis via maintaining the KEAP1-PGAM5 interaction

[ 24 ]Phytoestrogen arctigenin preserves the mucus barrier in inflammatory bowel diseases by inhibiting goblet cell apoptosis via the ERβ/TRIM21/PHB1 pathway

[ 25 ]Ginsenoside Rk1 inhibits HeLa cell proliferation through an endoplasmic reticulum signaling pathway

[ 26 ]The m6A Methyltransferase METTL3-Mediated N6-Methyladenosine Modification of DEK mRNA to Promote Gastric Cancer Cell Growth and Metastasis

[ 27 ]A Natural product-based composite nanozyme synergistically induces ferroptosis for lung cancer therapy

[ 28 ]Chk1 Inhibition Ameliorates Alzheimer’s Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling

[ 29 ]Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice

[ 30 ]Salvianolic Acid Ameliorates Pressure Overload-Induced Cardiac Endothelial Dysfunction via Activating HIF1α/HSF1/CD31 Pathway

[ 31 ]Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU

[ 32 ]Tianma Gouteng Decoction Exerts Pregnancy-Protective Effects Against Preeclampsia via Regulation of Oxidative Stress and NO Signaling.

[ 33 ]Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction

[ 34 ]Coumarin Derivative N6 as a Novel anti-hantavirus Infection Agent Targeting AKT

[ 35 ]Anoctamin 5 promotes osteosarcoma development by increasing degradation of Nel-like proteins 1 and 2

[ 36 ]Yi-Qi-Jian-Pi formula ameliorates immune function in acute-on-chronic liver failure by upregulating autophagy and mitochondrial biogenesis in CD8+ T lymphocytes

[ 37 ]Identification of inflammatory response and alternative splicing in acute kidney injury and experimental verification of the involvement of RNA‑binding protein RBFOX1 in this disease

[ 38 ]Transferrin Receptor Functionally Marks Thermogenic Adipocytes

[ 39 ]V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity

[ 40 ]PPARγ as an E3 Ubiquitin-Ligase Impedes Phosphate-Stat6 Stability and Promotes Prostaglandins E2-Mediated Inhibition of IgE Production in Asthma

[ 41 ]Selective PPARγ modulator diosmin improves insulin sensitivity and promotes browning of white fat

[ 42 ]A Comprehensive Analysis of Physiologic and Hormone Basis for the Difference in Room-Temperature Storability between ‘Shixia’ and ‘Luosanmu’ Longan Fruits

[ 43 ]Integrated transcriptomic and metabolomic analysis of intestinal responses of Litopenaeus vannamei under acute freshwater stress

[ 44 ]Inhibition of PLK4 might enhance the anti-tumour effect of bortezomib on glioblastoma via PTEN/PI3K/AKT/mTOR signalling pathway

[ 45 ]EIF2AK2 selectively regulates the gene transcription in immune response and histones associated with systemic lupus erythematosus

[ 46 ]Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro

[ 47 ]Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway

[ 48 ]Knockdown of circ-FURIN suppresses the proliferation and induces apoptosis of granular cells in polycystic ovary syndrome via miR-195-5p/BCL2 axis

[ 49 ]RNA analysis of diet-induced sarcopenic obesity in rats

[ 50 ]Isoquercitrin inhibits Streptococcus pneumoniae-induced pyroptosis of BEAS-2B cells by SIRT1-mediated acetylation

[ 51 ]Efficient control of Tribulium castaneum using zeolitic imidazolate framework-8 nanocarrier-mediated delivery of dsRNA targeting Paramyosin

[ 52 ]Infectome Landscape of Rodents and Shrews in Guangdong Province Reveals Diverse Pathogens with Zoonotic Potential in Wildlife

[ 53 ]TRPV-mediated capsaicin-induced feeding promotion and growth enhancement in sea cucumber Apostichopus japonicus: First evidence in echinoderms

[ 54 ]Repression of the expression of proinflammatory genes by mitochondrial transcription factor A is linked to its alternative splicing regulation in human lung epithelial cells

[ 55 ]MapZ deficiency leads to defects in the envelope structure and changes stress tolerance of Streptococcus mutans

[ 56 ]Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489–3p/Sirt1 axis

[ 57 ]CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis

[ 58 ]Fatty acid synthase (Fasn) inhibits the expression levels of immune response genes via alteration of alternative splicing in islet cells

[ 59 ]KSRP-dependent immunogenic cell death induced by pyridazinone derivative IMB5036 drives antitumor immunity in neuroblastoma

[ 60 ]Molecular carriers enable precision delivery and region-specific neuroprotection by dietary DHA in the mouse brain

[ 61 ]Helicobacter pylori-induced protein tyrosine phosphatase receptor type C as a prognostic biomarker for gastric cancer

[ 62 ]Tilianin attenuates MPP+‑induced oxidative stress and apoptosis of dopaminergic neurons in a cellular model of Parkinson's disease

[ 63 ]MMP7 damages the integrity of the renal tubule epithelium by activating MMP2/9 during ischemia–reperfusion injury

[ 64 ]Napabucasin Attenuates Resistance of Breast Cancer Cells to Tamoxifen by Reducing Stem Cell-Like Properties

[ 65 ]The Na+/K+ ATPase Inhibitor Ouabain Attenuates Stemness and Chemoresistance of Osteosarcoma Cells

[ 66 ]UBE2T promotes proliferation and regulates PI3K/Akt signaling in renal cell carcinoma

[ 67 ]The establishment of a GPD1L knockout human embryonic stem cell line (WAe009-A-80) using the CRISPR/Cas9 system