Baricitinib phosphate巴瑞克替尼磷酸盐(LY3009104/INCB028050 phosphate) JAK1/JAK2抑制剂|CAS 1187595-84-1（52998ES）

Baricitinib phosphate (LY3009104 phosphate，INCB028050 phosphate)，又称巴瑞克替尼磷酸盐，是一种选择性、ATP竞争性、可口服的JAK1/2抑制剂，IC₅₀值为5.9 nM和5.7 nM，对JAK3和Tyk2抑制活性较低，对c-Met和Chk2没有抑制作用。Baricitinib常用于治疗成人中中度至重度的活动性类风湿关节炎。

参考文献

1.Fridman JS, et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol. 2010;184 (9):5298-307.

2.Jabbari A, et al. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib. EBioMedicine. 2015;2 (4):351-5.

3.Khan IM, et al. Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance. Int J Obes (Lond) . 2015;39 (11):1607-18.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃避光保存，避免反复冻融。