Otenabant Hydrochloride (CP 945598 Hydrochloride, CP-945598 HCl, Otenabant HCl)，又称奥替那班盐酸盐，是一种大麻素受体(CB1)的选择性拮抗剂，K_i为0.7 nM；作用于人CB2受体，亲和力低，K_i为7.6 μM。大麻素受体CB1参与多种生理过程，包括情绪食欲调节、脂质代谢、认知以及免疫等。

参考文献

[1] Griffith DA, et al. Discovery of 1-[9-(4-chlorophenyl) -8-(2-chlorophenyl)- 9H-purin-6-yl] -4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. J Med Chem. 2009 Jan 22;52(2):234-7.

[2] Hadcock JR, et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB(1) receptor antagonist for the management of obesity. Biochem Biophys Res Commun. 2010 Apr 2;394(2):366-71.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议分装后-25~-15℃干燥保存，避免反复冻融。