盐酸胺碘酮Amiodarone hydrochloride sodium/potassium-ATPase抑制剂|CAS 19774-82-4（53760ES）

Amiodarone hydrochloride (Amiodarone HCl, NSC 85442 HCl)，又称盐酸胺碘酮，是III类抗心律失常药物，用于治疗各种心律失常；也是一种sodium/potassium-ATPase抑制剂，通过抑制钾通道和电压门控钠通道来延长心房和心室的肌纤维动作电位时程，可导致心率和血管阻力降低。

参考文献

1. Yihong Zhang,et al. Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking. Biochem Pharmacol. 2016 Aug 1;113:24-35.
2. Jie Weng, et al. Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Biomed Pharmacother. 2019 Jul;115:108889.
3. Sabrina Le Bouter, et al. Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart. Circulation. 2004 Nov 9;110(19):3028-35.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。