Magnolin（木兰苷，木兰脂素）是木兰科辛夷花蕾的主要成分，靶向作用于ERK1 和 ERK2，其IC₅₀值分别为 87 nM 和 16.5 nM，抑制ERKs/RSK2/Ras信号通路，抑制caspase-3活性，上调Bcl-2表达水平，改善肾小管坏死、细胞凋亡及肾功能恶化的情况，具有抗过敏、抗炎、降压和抑菌的作用。

参考文献

[1]. Lee CJ, et al. Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway. BMC Cancer. 2015 Aug 8; 15:576. 

[2]. Wang F, et al. Magnolin protects against contrast-induced nephropathy in rats via antioxidation and antiapoptosis. Oxid Med Cell Longev. 2014; 22014:203458.

[3]. Cheol-Jung L, et al. Targeting of magnolin on ERKs inhibits Ras/ERKs/RSK2-signaling-mediated neoplastic cell transformation[J]. Carcinogenesis, 2014(2):432-441.

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