SKL 2001 (SKL2001)是Wnt/β-catenin信号通路的激动剂，可上调其下游靶点Axin2的表达。SKL 2001与Axin竞争性地结合β-catenin，破坏Axin/β-catenin相互作用，增加β-catenin稳定性，具有抗肿瘤活性。

参考文献

1.Gwak J, et al. Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation. ell Res. 2012 Jan;22(1):237-47.

2.Ohashi W, et al. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. Biochem Biophys Res Commun. 2017 Nov 25;493(3):1342-1348.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。