光照节律紊乱通过时钟基因改变和氧化-炎症反应导致大鼠心脏重塑

Abstract

Here we systematically compared the cardiovascular effects of continuous light (LL) and reversed 48-hour light-dark cycle (LD-DL) exposure in Sprague-Dawley rats over 20 weeks. Both disrupted light conditions were associated with significant cardiovascular dysfunction, including elevated blood pressure and increased heart rate, along with myocardial hypertrophy, cardiac enlargement, collagen fibrosis, and apoptosis. Notably, the LD-DL group exhibited more pronounced oxidative stress (elevated ROS, downregulated Nrf2) and inflammatory responses (enhanced inflammatory cell infiltration, upregulated IL-6 and IL-1β), whereas the LL group showed more pronounced cardiac structural remodeling despite moderate inflammation. Both paradigms were accompanied by suppressed melatonin levels and altered clock gene expression. These findings suggest that distinct light disruption patterns may be associated with cardiovascular injury through different mechanisms—LL predominantly characterized by hemodynamic parameters and structural remodeling, LD-DL preferentially linked to oxidative-inflammatory responses—highlighting the need for paradigm-specific therapeutic strategies.