Nutlin-3a(Rebemadlin) MDM2抑制剂|CAS 675576-98-4（53741ES）

Nutlin-3a (Rebemadlin, (-)-Nutlin-3, Nutlin3a)是Nutlin-3的活性对映体，是MDM2抑制剂，IC₅₀为90 nM，通过竞争性结合MDM2的TP53结合口袋，抑制p53/MDM2相互作用并稳定p53蛋白，在表达 p53的细胞中表现出出强效的抗增殖活性。

参考文献

1.Crane EK, et al. Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas. PLoS One. 2015 Aug 6;10(8):e0135101.

2.Tovar C, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93.

3.M Ulrich, et al. Murine tumor models for the in vivo evaluation of natural compounds and their derivatives as new cancer therapeutics. München. 2016.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。