Name: 放线菌素D(更生霉素) Actinomycin D 多肽抗生素|CAS 50-76-0（53600ES）
Brand: 翌圣生物
SKU: 53600ES
Price: 425 CNY
Availability: InStock

Actinomycin D放线菌素D

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Actinomycin D (Dactinomycin, Actinomycin IV, Act D, RASP-101, RASP101)，又称放线菌素D或更生霉素，是一种从链霉菌属的土壤细菌中的分离的多肽抗生素，与双链DNA结合形成稳定复合物，从而抑制DNA修复，还会导致DNA的单链断裂，抑制RNA的合成，作用于mRNA干扰细胞的转录过程，还可使细胞周期停滞在G1期，进而抑制细胞增殖。放线菌素D可提高放射敏感性，与放射治疗同时使用，可提高肿瘤对放射的敏感性。

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参考文献

[1] Barret JM, et al. Evaluation of DNA repair inhibition by antitumor or antibiotic drugs using a chemiluminescence microplateassay. Carcinogenesis. 1997 Dec;18(12):2441-5.

[2] Wu CH, et al. The molecular mechanism of actinomycin D in preventing neointimal formation in rat carotid arteries after balloon injury. J Biomed Sci. 2005;12(3):503-12.

[3] Merkel O, et al. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia. 2012 Dec;26(12):2508-16.

存储条件

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。产品对光敏感，避光保存。

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