HLY78 (HLY-78)是Wnt/β-catenin信号通路的激活剂，通过靶向Axin蛋白的DIX结构域，促进Axin-LRP6结合，导致LRP6的磷酸化，进而提高了Wnt信号的激活效率。HLY78能够依赖Wnt信号显著提高造血干细胞的数量。

参考文献

1.Wang S, et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85.

2.Luo X, et al. HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats. Neurosci Bull. 2020 Oct;36(10):1171-1181.

3.Si J, et al. Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity. Toxicology. 2019 Jan 1;411:143-153.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。