Pimozide D4(SKI-606 D8) dopamine receptor拮抗剂|CAS 1803193-57-8（53208ES）

Pimozide D4 (SKI-606 D8)是Pimozide的氘代物，是通过GC或LC-MS定量Pimozide的标志物，是dopamine receptor的拮抗剂，作用于dopamine D1/2/3 receptor的K_i值分别为588 nM、1.4 nM、2.5 nM。

参考文献

1.Ybema CE, et al. Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan. Eur J Pharmacol. 1994 Apr 21;256(2):141-7.

2.Cai N, et al. The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. Am J Transl Res. 2017 Aug 15;9(8):3853-3866. eCollection 2017.

3.Erik A. Nelson, et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011 Mar 24; 117(12): 3421-3429.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃避光保存，避免反复冻融。