RIPA裂解液(强)|RIPA lysis buffer(strong) 裂解缓冲液（20101ES）

[ 1 ]A metabolic alarmin from keratinocytes potentiates systemic humoral immunity

[ 2 ]Exacerbation of allergic rhinitis by the commensal bacterium Streptococcus salivarius

[ 3 ]Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

[ 4 ]FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival

[ 5 ]FOXI3 establishes the ectodermal niche in pharyngeal arches for cranial neural crest cells and their lineages

[ 6 ]The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling TH2 to TH17 cell conversion via interleukin-4-STAT5 axis in mice

[ 7 ]A compact and inducible dCas12f-based CRISPRa platform for programmable in vivo gene activation

[ 8 ]Molecular basis of host ATP level modulation by actin-dependent secreted bacterial ATPase and its metaeffector

[ 9 ]Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming

[ 10 ]Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice

[ 11 ]Combinatorial Design of Fatty Acid-Incorporated Plasmid Lipid Nanoparticles Drives Dendritic Cell Hyperactivation for Enhanced Cancer Immunotherapy

[ 12 ]Enhancer architecture-dependent multilayered transcriptional regulation orchestrates RA signaling-induced early lineage differentiation of ESCs

[ 13 ]Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas

[ 14 ]Magnesium-tannic acid nanomedicines reprogram pro-fibrotic macrophages for hepatic fibrosis treatment via restoring endoplasmic reticulum homeostasis

[ 15 ]Cholesterol-depleted macrophage membrane-coated nano-rapamycin for targeted atherosclerosis therapy

[ 16 ]LACC1 attenuates LPS-induced acute lung injury by inhibiting inflammatory response in alveolar macrophage through LPAR3/PI3K/AKT/mTOR signaling pathway

[ 17 ]Ferroptotic tumor cells reprogram tumor-associated macrophage antigen presentation to enhance the efficacy of immune checkpoint blockade

[ 18 ]A short period of early life oxytocin treatment rescues social behavior dysfunction via suppression of hippocampal hyperactivity in male mice

[ 19 ]TOLLIP-mediated autophagic degradation pathway links the VCP-TMEM63A-DERL1 signaling axis to triple-negative breast cancer progression

[ 20 ]Tumor progress intercept by intervening in Caveolin-1 related intercellular communication via ROS-sensitive c-Myc targeting therapy

[ 21 ]Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating EGFR/AKT/NF-kB/IkB signaling

[ 22 ]Myosin VI drives breast cancer progression via SP1/CA9-mediated acidic tumor microenvironment remodeling and subsequent M2 macrophage polarization

[ 23 ]Glycogen synthase 1 promotes breast cancer progression by promoting IκBα ubiquitination and degradation independent of its canonical enzyme function

[ 24 ]PKC activators improve the function of biogenesis-deficient CFTR channels

[ 25 ]Afzelin resists UVA damage through autophagy and synergizes with ganoderic acid A to skin photoaging

[ 26 ]CRYL1 inhibits tumorigenesis and metastasis in clear cell renal cell carcinoma through upregulation of CASR

[ 27 ]Original research: ANKRD22 is a potential novel target for reversing the immunosuppressive effects of PMN-MDSCs in ovarian cancer

[ 28 ]Arsenic retention in erythrocytes and excessive erythrophagocytosis is related to low selenium status by impaired redox homeostasis

[ 29 ]Soft substrates promote direct chemical reprogramming of fibroblasts into neurons

[ 30 ]Freeze-casting osteochondral scaffolds: The presence of a nutrient-permeable film between the bone and cartilage defect reduces cartilage regeneration

[ 31 ]Astrocytic connexin 43 hemichannel dysregulation drives prefrontal circuit dysfunction and schizophrenia-like behaviors

[ 32 ]Clemastine alleviates cognitive dysfunction after SAH by targeting neuronal CNTN1 to regulate the ADA-adenosine pathway

[ 33 ]Aquaporin 11 alleviates retinal Müller intracellular edema through water efflux in diabetic retinopathy

[ 34 ]DCBLD1 Promotes Lung Tumorigenesis by Inhibiting PTP1B Dephosphorylation of EGFR

[ 35 ]The PTBP1-EZH2-DOCK2 axis promotes M1 microglial polarization and exacerbates neuronal apoptosis following spinal cord injury

[ 36 ]Therapeutic inhibition of PPARα-HIF1α-PGK1 signaling targets leukemia stem and progenitor cells in acute myeloid leukemia

[ 37 ]Juxtamembrane 2 mimic peptide competitively inhibits mitochondrial trafficking and activates ROS-mediated apoptosis pathway to exert anti-tumor effects

[ 38 ]The structural basis for glycerol permeation by human AQP7

[ 39 ]USP39 stabilizes β-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression

[ 40 ]Melatonin Maintains Inner Blood–Retinal Barrier by Regulating Microglia via Inhibition of PI3K/Akt/Stat3/NF-κB Signaling Pathways in Experimental Diabetic Retinopathy

[ 41 ]MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment

[ 42 ]MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor

[ 43 ]Protective effect of resveratrol against colistin-induced nephrotoxicity through regulating Nrf2 pathway and inhibiting ferroptosis

[ 44 ]Retrograde regulation of mitochondrial fission and epithelial to mesenchymal transition in hepatocellular carcinoma by GCN5L1

[ 45 ]Lamin A/C safeguards replication initiation by orchestrating chromatin accessibility and PCNA recruitment

[ 46 ]Erythropoietin protects the inner blood–retinal barrier by inhibiting microglia phagocytosis via Src/Akt/cofilin signalling in experimental diabetic retinopathy

[ 47 ]PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα

[ 48 ]Efficient iron utilization compensates for loss of extracellular matrix of ovarian cancer spheroids

[ 49 ]Decreased expression of IDH1 by chronic unpredictable stress suppresses proliferation and accelerates senescence of granulosa cells through ROS activated MAPK signaling pathways

[ 50 ]Nicandra physalodes Extract Exerts Antiaging Effects in Multiple Models and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1

[ 51 ]Never-in-Mitosis A-Related Kinase 8 (NEK8) Regulates Adipogenesis, Glucose Homeostasis, and Obesity

[ 52 ]Discovery of Novel MDH2 Inhibitor 28i by Secondary Development of Glibenclamide with Potent Antiaging Activities

[ 53 ]Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression

[ 54 ]Comparison of RNA m6A and DNA methylation profiles between mouse female germline stem cells and STO cells

[ 55 ]circPVT1 regulates EMT and induces macrophage polarization to promotes the progression of renal cell carcinoma

[ 56 ]FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression

[ 57 ]Hsa_circ_0039569 facilitates the progression of endometrial carcinoma by targeting the miR-197/high mobility group protein A1 axis

[ 58 ]MiRNA-99a alleviates inflammation and oxidative stress in lipopolysaccharide-stimulated PC-12 cells and rats post spinal cord injury

[ 59 ]Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis

[ 60 ]C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 7(CXCR7) regulates epithelial-mesenchymal transition process and promotes the metastasis of esophageal cancer by activating signal transducer and activator of transcription 3 (STAT3) pathway

[ 61 ]Noncoding-RNA mediated high expression of zinc finger protein 268 suppresses clear cell renal cell carcinoma progression by promoting apoptosis and regulating immune cell infiltration

[ 62 ]Integrated bioinformatics and machine learning approaches reveal that Venenum bufonis acts against acute pharyngitis by inhibiting the p38 MAPK/ERK-MKNK1-eIF4E signaling pathway

[ 63 ]Adiponectin improves the aortic dissection by inhibiting inflammatory cell infiltration and macrophage pyroptosis

[ 64 ]Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist

[ 65 ]Daidzein Activates Akt Pathway to Promote the Proliferation of Female Germline Stem Cells through Upregulating Clec11a

[ 66 ]BMSC-Derived Small Extracellular Vesicles Induce Cartilage Reconstruction of Temporomandibular Joint Osteoarthritis via Autotaxin–YAP Signaling Axis

[ 67 ]FOXO4 Inhibits the Migration and Metastasis of Colorectal Cancer by Regulating the APC2/β-Catenin Axis

[ 68 ]SP1-Mediated Upregulation of Long Noncoding RNA ZFAS1 Involved in Non-syndromic Cleft Lip and Palate via Inactivating WNT/β-Catenin Signaling Pathway

[ 69 ]Sphingomyelin-Sequestered Cholesterol Domain Recruits Formin-Binding Protein 17 for Constricting Clathrin-Coated Pits in Influenza Virus Entry

[ 70 ]Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice

[ 71 ]GSK2879552 inhibits NLRP3 inflammasome-mediated pyroptosis and acute lung injury through NOX2-ROS signalling axis

[ 72 ]Solanum nigrum L.-derived nanovesicles as novel nanotherapeutics suppressing prostate cancer progression via senescence-based antitumor activity

[ 73 ]Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis

[ 74 ]SARS-CoV-2 receptor binding domain radio-probe: a non-invasive approach for angiotensin-converting enzyme 2 mapping in mice

[ 75 ]Pretreatment with chitosan oligosaccharides attenuate experimental severe acute pancreatitis via inhibiting oxidative stress and modulating intestinal homeostasis

[ 76 ]Multi-Omics Analysis of the Therapeutic Value of MAL2 Based on Data Mining in Human Cancers

[ 77 ]Cytotoxic Effect of a β1,4-Galactosyltransferase Inhibitor in Hepatic Carcinoma Cells

[ 78 ]Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors

[ 79 ]Flaxseed Powder Attenuates Non-Alcoholic Steatohepatitis via Modulation of Gut Microbiota and Bile Acid Metabolism through Gut–Liver Axis

[ 80 ]GAS5/miR-21 Axis as a Potential Target to Rescue ZCL-082-Induced Autophagy of Female Germline Stem Cells In Vitro

[ 81 ]Antibiotics administration during weaning ameliorates intestinal mucosal inflammation in adult mice and their offspring

[ 82 ]Characterization and Heterologous Expression of UDP-Glucose 4-Epimerase From a Hericium erinaceus Mutant with High Polysaccharide Production

[ 83 ]Improvement of Non-Alcoholic Fatty Liver Disease in Mice by Intermittent Use of a Fasting-Mimicking Diet

[ 84 ]Inter-Fighting between Influenza A Virus NS1 and β-TrCP: A Novel Mechanism of Anti-Influenza Virus

[ 85 ]Triptolide Shows High Sensitivity and Low Toxicity Against Acute Myeloid Leukemia Cell Lines Through Inhibiting WSTF-RNAPII Complex.

[ 86 ]LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability

[ 87 ]C89 Induces Autophagy of Female Germline Stem Cells via Inhibition of the PI3K-Akt Pathway In Vitro

[ 88 ]CRISPR/Cas9-mediated knockout of NSD1 suppresses the hepatocellular carcinoma development via the NSD1/H3/Wnt10b signaling pathway

[ 89 ]Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7

[ 90 ]TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway

[ 91 ]A Photothermally Active CuS-Nanocomposite Hydrogel for Postsurgical Melanoma Management and Tissue Regeneration

[ 92 ]Panaxadiol saponin ameliorates ferroptosis in iron-overload aplastic anemia mice and Meg-01 cells by activating Nrf2/HO-1 and PI3K/AKT/mTOR signaling pathway

[ 93 ]Carboxylated Agarose (CA)-Silk Fibroin (SF) Dual Confluent Matrices Containing Oriented Hydroxyapatite (HA) Crystals: Biomimetic Organic/Inorganic Composites for Tibia Repair

[ 94 ]Buyang Huanwu Decoction Attenuates Infiltration of Natural Killer Cells and Protects Against Ischemic Brain Injury

[ 95 ]Polysaccharides from Ulva prolifera O.F. Müller inhibit cell proliferation via activating MAPK signaling in A549 and H1650 cells

[ 96 ]Transcriptomic analysis reveals that the anti-PCOS effects of Zishen Qingre Lishi Huayu recipe may involve pathways and genes related to autophagy, steroidogenesis, oxidative stress, and inflammation in granulosa cells

[ 97 ]Homeostatic Regulation of Astrocytes by Visual Experience in the Developing Primary Visual Cortex

[ 98 ]124I Radiolabeled Basiliximab for CD25-Targeted Immuno-PET Imaging of Activated T Cells

[ 99 ]Novel insights into antidepressant mechanism of Kai Xin San formula: Inhibiting NLRP3 inflammasome activation by promoting autophagy

[ 100 ]Deciphering the synergistic network regulation of active components from SiNiSan against irritable bowel syndrome via a comprehensive strategy: Combined effects of synephrine, paeoniflorin and naringin