PLAAT1 promotes p53 degradation via autophagy-lysosome pathway in zebrafish
Xin Zhao, Wenji Huang, Jiahong Guo, Ning Ji, Jianhua Feng, Yanjie Shi, Kangyong Chen, Jun Zou
Journal：FISH & SHELLFISH IMMUNOLOGY
IF：4.62
DOI：10.1016/j.fsi.2022.05.001
PMID：35526800
Published：2022-05-05
research field：分子生物学靶向药物递送癌症治疗学细胞信号转导生物偶联化学
Abstract
PLAAT1 belongs to the PLAAT family and plays regulatory roles in cell growth, tumor suppression and phospholipid metabolism . However, whether PLAAT1 is involved in p53 mediated signaling has not been investigated. Here, we report that PLAAT1 promotes degradation of p53 in zebrafish. We found that the plaat1 gene was constitutively expressed in tissues including liver, kidney , spleen , intestine, eye and brain , with relative higher expression levels detected in the brain and eye. Overexpression of plaat1 led to inhibition of p53 and tnfα mRNA expression. Furthermore, it was shown that PLAAT1 interacted with p53 to facilitate p53 degradation via autophagy-lysosome dependent pathway. Our work indicates that PLAAT1 is involved in the interplay between p53 mediated cellular responses and autophagy.
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