MCC-135通过下调NCX1表达减轻钙超载发挥抗癫痫和神经保护作用
MCC‐135 Exerts Antiepileptic and Neuroprotective Effects by Downregulating NCX1 Expression to Decrease Intracellular Calcium Overload in the Hippocampus
Chaoning Liu, Min He, Rida Li, Shouhuan Zheng, Lanfeng Sun, Chi Gong, Hengchang Qi, Xinran Qin, Xiaohang Gan, Fang Wang, Yuan Wu
Journal：CNS Neuroscience & Therapeutics
IF：6.6
DOI：10.1002/cns.70808
PMID：41772763
Published：2026-03-02
research field：神经科学神经药理学
Abstract
MCC‐135 treatment significantly prolonged the seizure latency and alleviated hippocampal neuronal damage in KA‐induced epileptic mice. Furthermore, MCC‐135 reduced NCX1 levels, alleviated intracellular calcium overload, and downregulated glutamate levels in the epileptic mice. We are the first to propose the role and mechanism of MCC‐135 in epilepsy treatment.
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