[ 1 ]Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling

[ 2 ]CLIM-TIME identifies metastatic microenvironment modulators for T cell therapy response

[ 3 ]Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2

[ 4 ]Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

[ 5 ]Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity

[ 6 ]Polymer–mRNA complexes for monocyte-trafficked, lymph node-targeted cancer vaccination

[ 7 ]NSUN6 deficiency drives immune suppression in pancreatic cancer via the KDM5A-CCL2-macrophage axis

[ 8 ]Hepatocyte-derived LRG1 primes the liver for metastasis and impairs immunotherapy

[ 9 ]Commensal enteric virome regulates intestinal carbohydrate digestion and absorption

[ 10 ]SPP1 Drives Colorectal Cancer Liver Metastasis and Immunotherapy Resistance by Stimulating CXCL12 Production in Cancer-Associated Fibroblasts

[ 11 ]Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration

[ 12 ]Itaconate is a lysosomal inducer that promotes antibacterial innate immunity

[ 13 ]Bafetinib enhances anti-tumor immunity by activating the NLRP3 inflammasome in macrophage

[ 14 ]Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar

[ 15 ]Deficiency of lysosomal TMEM175 in myeloid macrophages exerts anti-tumor immunity via inflammasome and cross-presentation pathway

[ 16 ]Engineered BCG selectively triggers trained immunity in tumor-associated macrophages and sensitizes glioblastoma to radiotherapy in mice

[ 17 ]Reprogramming macrophage immunometabolism via glutamine antagonism potentiates colorectal cancer therapy in mice

[ 18 ]Mammary Leukocyte-Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery

[ 19 ]PRL-3 up-regulates exosomal ITGαvβ5 expression to promote liver pre-metastatic niche formation and colon cancer liver metastasis

[ 20 ]Localized Depletion of Macrophages by Abdominal Cavity Retention Nanoparticles as a Potential Therapy for Peritoneal Metastasis

[ 21 ]A regenerative and programmable iPSC-derived platelet platform for universal drug delivery and immunotherapy

[ 22 ]Stromal Cell-Derived Itaconate Promotes Endometriosis via Macrophage NRF2 and Lysosomal pH Modulation

[ 23 ]Overconsumption of fructose aggravates acute GVHD by inducing gut dysbiosis and promoting macrophage-mediated inflammatory response

[ 24 ]In vivo generation of fibrolytic macrophages via LNP-CSF1 mRNA attenuates liver fibrosis

[ 25 ]Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury

[ 26 ]Meningeal macrophages regulate fibroblasts to influence meningeal lymphatic function following traumatic brain injury

[ 27 ]Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice

[ 28 ]BMAL1 regulates tubular epithelial-derived exosomal miR-27a-3p to inhibit macrophage–myofibroblast transition and alleviate ischemia/reperfusion-induced renal fibrosis

[ 29 ]Progranulin drives acetaminophen-induced acute liver injury by limiting hepatic recruitment of eosinophils via suppressing interleukin-33 expression

[ 30 ]IFI30 reprograms glioblastoma-associated macrophage and induces immune evasion by MAFF/PTGS2 pathway

[ 31 ]CD163+ macrophages coordinate erythroblastic Island formation and iron metabolism to enable glucocorticoid-induced erythropoiesis

[ 32 ]PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

[ 33 ]Context-Dependent Role of GDF15: GDF15+ Tumor-Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

[ 34 ]Cryoablation Activates the cGAS–STING-CXCL10 Axis in Macrophages to Enhance Anti-Tumor Immunity in NSCLC

[ 35 ]Macrophage–Derived Ferritin Exacerbates Silica-Induced Pulmonary Fibrosis via PIK3R2-Mediated Fibroblast Differentiation

[ 36 ]Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

[ 37 ]HRS Degradation-Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal-Fetal Immune Homeostasis

[ 38 ]Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

[ 39 ]S100A8/A9-High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15-CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

[ 40 ]Dual PD-1/IL-2Rα targeting restores CD8+ T cell fitness via STAT5/CD47 axis in SMARCA4-deficient NSCLC

[ 41 ]d-amino acids restrain macrophage IL-1β release through gasdermin D acetylation

[ 42 ]Integrated Single-Cell Profiling Reveals TL1A as a Biomarker and Driver of Type 2 Inflammation via Macrophage-Dependent Immunoregulation in Asthma

[ 43 ]Transfection with Plasmid-Encoding lncRNA-SLERCC nanoparticle-mediated delivery suppressed tumor progression in renal cell carcinoma

[ 44 ]Original research: Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization

[ 45 ]PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way

[ 46 ]A bone-marrow-homing biomimetic STING nanoinhibitor alleviates radiation-induced hematopoietic injury via modulating macrophage polarization

[ 47 ]Melanoma exosomal miR-708-5p promotes macrophage M2 polarization and cancer metastasis

[ 48 ]Ripk2 promotes CD8+ T cell inactivation and hepatocellular carcinoma progression through Myb/Cxcl9 and Pax5/Adpgk signaling pathways

[ 49 ]Depletion of macrophages during early postnatal development leads to disrupted tooth root development and altered Gli1⁺ MSC trajectory

[ 50 ]MTFR2 promotes VDAC1 oligomerization to reprogram BCAA metabolism in tumor cells to polarize TAMs in LUAD

[ 51 ]PRAS40-driven pro-inflammatory macrophage polarization is required for inflammatory bowel disease

[ 52 ]Tamoxifen enhances radiation efficacy by promoting M1 polarization of tumor associated macrophages via JNK/c-JUN pathway

[ 53 ]Targeting tumor cell-intrinsic POU4F1 enhances antitumor immunity and sensitizes tumors to immunotherapy in basal-like breast cancer by modulating macrophage recruitment and polarization

[ 54 ]Targeting Macrophage-to-Myofibroblast Transition Mitigates Progression from Inflammation to Fibrosis in Rosacea

[ 55 ]Gasdermin D antagonizes immunosuppression in prostate cancer by inducing LAMC2 degradation to block M2 macrophage polarization

[ 56 ]USP1-mediated lipophagy-lipogenesis axis drives cholangiocarcinoma progression and immune evasion

[ 57 ]Myosin VI drives breast cancer progression via SP1/CA9-mediated acidic tumor microenvironment remodeling and subsequent M2 macrophage polarization

[ 58 ]TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization

[ 59 ]Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury

[ 60 ]AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages

[ 61 ]Intravital imaging of interactions between iNKT and kupffer cells to clear free lipids during steatohepatitis

[ 62 ]Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B

[ 63 ]Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway

[ 64 ]Functional Restoration of Uterine Architecture and Fertility via a 3D-Printed Biomimetic Scaffold: The Role of Macrophage-Driven Immunomodulation

[ 65 ]HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3

[ 66 ]Unveiling a macrophage-driven inflammatory dysregulation: NF-κB-mediated hyperinflammation links 6PPD-Q exposure to viral immunopathology

[ 67 ]Resibufogenin promotes angiogenesis via the VAV3-mediated ITGA5–VEGF signaling axis in macrophages to alleviate myocardial infarction

[ 68 ]Excessive pyroptosis mediates the exacerbation of pneumonia caused by low-lethality influenza virus and secondary MRSA co-infection

[ 69 ]AI-driven pipeline discovers ombuin as a novel M1 macrophage polarization inhibitor for sepsis treatment

[ 70 ]Lidocaine suppresses lung cancer metastasis by inhibiting polarisation of tumour-associated macrophages in mice

[ 71 ]Medicinal plant-derived mtDNA via nanovesicles induces the cGAS-STING pathway to remold tumor-associated macrophages for tumor regression

[ 72 ]Aberrant Mesenteric Adipose Extracellular Matrix Remodelling is Involved in Adipocyte Dysfunction in Crohn’s Disease: The Role of TLR-4-mediated Macrophages

[ 73 ]GABA regulates IL-1β production in macrophages

[ 74 ]Trophoblast-Derived Extracellular Vesicles Promote Preeclampsia by Regulating Macrophage Polarization

[ 75 ]Mitochondrial DNA released from pyroptotic synovial macrophages via DDIT3-mediated mitophagy aggravates osteoarthritis progression

[ 76 ]FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis

[ 77 ]The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation

[ 78 ]USP39 stabilizes β-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression

[ 79 ]Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions

[ 80 ]Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

[ 81 ]EZH2 Inhibitors Suppress Colorectal Cancer by Regulating Macrophage Polarization in the Tumor Microenvironment

[ 82 ]Zinc finger protein 544 promotes hepatocellular carcinoma by generating an immunosuppressive tumor microenvironment

[ 83 ]Gut commensal Clostridium sporogenes-derived 5-aminovaleric acid attenuates liver injury by suppressing M1 macrophage activation in mice

[ 84 ]Kynurenic Acid/GPR35 Signaling Protects the Infarcted Heart by Suppressing Macrophage mtDNA-Triggered cGAS-STING Activation

[ 85 ]CD137 promotes bone metastasis of breast cancer by enhancing the migration and osteoclast differentiation of monocytes/macrophages

[ 86 ]Fatty Acid Binding Protein 4 (FABP4): a Key Player in Neuroinflammation and Neuropathic Pain

[ 87 ]The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon

[ 88 ]Lipid metabolic reprogramming of macrophage by host APOBEC3 deficiency enhances anti-tumor immunity

[ 89 ]Lactobacillus delbrueckii surface protein P4430 attenuates intestinal inflammation by modulating macrophage polarization via Mincle

[ 90 ]Targeting EP2/EP4-driven expansion of suppressive VSIG4high macrophages overcomes immunotherapy resistance in colorectal cancer

[ 91 ]Macrophage glycine transporter supports IL-1β production by modulating the AKT1/mTOR/NLRP3 pathway

[ 92 ]Fpr2/CXCL1/2 Controls Rapid Neutrophil Infiltration to Inhibit Streptococcus agalactiae Infection

[ 93 ]A Novel Anti-Infective Peptide BCCY-1 With Immunomodulatory Activities

[ 94 ]Circulating Ly6Chigh monocyte-derived S100A4+ macrophages exacerbate neuroinflammation and impede recovery of traumatic brain injury

[ 95 ]Tyrosine-protein phosphatase non-receptor type 2 deficiency in macrophages diminishes the anti-inflammatory and cardioprotective effects of gabapentin after myocardial infarction

[ 96 ]TLR2-hif1α-mediated glycolysis contributes to pyroptosis and oxidative stress in allergic airway inflammation

[ 97 ]Ginkgetin targets GRP78 to induce dual pathways of ER stress and immune activation in osteosarcoma

[ 98 ]Osteopontin aggravates acute lung injury in influenza virus infection by promoting macrophages necroptosis

[ 99 ]Mesenchymal stem cells alleviate systemic sclerosis by inhibiting the recruitment of pathogenic macrophages

[ 100 ]Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production