Rabeprazole sodium（LY307640 sodium）属于第二代质子泵抑制剂（PPI），可通过不可逆抑制胃H+/K+-ATP酶活性而发挥药理作用。该化合物能够诱导细胞凋亡，并对尿苷核苷核糖水解酶（UNH）表现出抑制效应，在胃溃疡及胃食管反流等相关疾病研究中具有应用价值。
|
英文别名 (English Synonym) |
Rabeprazole sodium |
|
中文名称 (Chinese Name) |
雷贝拉唑钠 |
|
靶点 (Target) |
Proton Pump |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
117976-90-6 |
|
分子式 (Formula) |
C18H20N3NaO3S |
|
分子量 (Molecular Weight) |
381.42 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Gu M, Zhang Y, Zhou X, Ma H, Yao H, Ji F. Rabeprazole exhibits antiproliferative effects on human gastric cancer cell lines. Oncol Lett. 2014 Oct;8(4):1739-1744. doi: 10.3892/ol.2014.2354. Epub 2014 Jul 16. PMID: 25202402; PMCID: PMC4156221. [2] Shaalan AAM, El-Sherbiny M, El-Abaseri TB, Shoaeir MZ, Abdel-Aziz TM, Mohamed MI, Zaitone SA, Mohammad HMF. Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels. Front Pharmacol. 2020 May 13;11:583. doi: 10.3389/fphar.2020.00583. PMID: 32477111; PMCID: PMC7237708.
