New chlorophenolic glycoside from Curculigo orchioides and their activities on 5α-reductase
Xue-Li Deng, Rui-Rong Zheng, Zhu-Zhen Han, Li-Hua Gu, Zheng-Tao Wang
Journal：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
IF：1.35
DOI：10.1080/10286020.2020.1731800
PMID：32131631
Published：2020-03-05
research field：肿瘤学分子生物学生物信息学药理学免疫学中医药学
Abstract
Two new chlorophenolic glucosides curculigines P (1) and Q (2), together with seven known compounds (3–9), were isolated from the dried rhizomes of Curculigo orchioides. Their structures were determined by spectroscopic methods including 1 D, 2 D NMR and MS. All the isolated compounds were evaluated on 5α-reductase activity by a HaCaT-based bioassay. Compounds 1–9 showed varying degrees of inhibiting activity against 5α-reductase, while compound 1 indicated the most potent inhibitory effect.
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