分子生物学
IVD分子诊断
细胞培养与分析
蛋白研究
细胞因子
重组蛋白
抗体
高通量测序建库
病原检测UCF系列
生物医药
工具酶
抑制剂激活剂与常用试剂
仪器
耗材

Self-shrinking soft demoulding for complex high-aspect-ratio microchannels

Fan Dongliang, Yuan Xi, Wu Wenyu, Zhu Renjie, Yang Xin, Liao Yuxuan, Ma Yunteng, Xiao Chufan, Chen Cheng, Liu Changyue, Wang Hongqiang, Qin Peiwu

Journal:Nature Communications

IF:17.69

DOI:10.1038/s41467-022-32859-z

PMID:36038593

Published:2022-08-29

research field:肿瘤学生物医学工程材料科学

Abstract

Microchannels are the essential elements in animals, plants, and various artificial devices such as soft robotics, wearable sensors, and organs-on-a-chip. However, three-dimensional (3D) microchannels with complex geometry and a high aspect ratio remain challenging to generate by conventional methods such as soft lithography, template dissolution, and matrix swollen processes, although they are widespread in nature. Here, we propose a simple and solvent-free fabrication method capable of producing monolithic microchannels with complex 3D structures, long length, and small diameter. A soft template and a peeling-dominant template removal process are introduced to the demoulding process, which is referred to as soft demoulding here. In combination with thermal drawing technology, microchannels with a small diameter (10 µm), a high aspect ratio (6000, length-to-diameter), and intricate 3D geometries are generated. We demonstrate the vast applicability and significant impact of this technology in multiple scenarios, including soft robotics, wearable sensors, soft antennas, and artificial vessels.

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